SSM Health and the healing power of presence

SSM Health St. Mary's Hospital - Centralia

400 N. Pleasant Ave.
Centralia, IL  62801

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Operating in partnership with the Felician Sisters, SSM Health St. Mary’s Hospital – Centralia has a strong history of over 100 years of community engagement. Our 125-bed, inpatient hospital specializes in several types of care including: behavioral health conditions, cancer, maternity, occupational medicine, weight management services, wound care and many more.

We’re the proud recipients of the Outstanding Patient Experience and Critical Care Excellence awards presented by Healthgrades for six consecutive years. We take pride in all of our accomplishments and it shows in how we take care of you and your family, day in and day out. Each and every day the compassionate employees and physicians at SSM Health St. Mary’s Hospital bring hope and healing to Centralia.

Plan your visit to St. Mary’s Hospital - Centralia

Visitor Information
SSM Health St. Mary's Hospital, Centralia, Illinois

woman successfully managing weight

What Do You Have to Lose?

Discover if weight-loss surgery is right for you.

Learn about our weight management services and explore your options.  We offer non-surgical and bariatric surgery services. 

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It's moments like this.

The Healing Power of Presence.

The better we know you as a person, the better we can treat you as a patient.

Watch these moments.


As a Commission on Cancer Accredited program, we provide you with the latest advances in cancer treatment as well as a supportive team of board-certified oncologists, specialists and nurse navigators to help you at every step.


SSM Health in Illinois uses state-of-the art telehealth technology to connect you with maternal-fetal medicine specialists​ at our sister hospital, SSM Health St. Mary's Hospital - St. Louis.

Behavioral Health

​​​​​​​​SSM Health offers one of the most comprehensive Behavioral Health programs in south-central Illinois. Our program includes a broad range of outpatient and inpatient services for both adults and seniors.

Occupational Medicine

We work to help safeguard the good health of a company's workforce by ensuring prompt access to care and reducing lost time. You can also complete your DOT physical at four locations in our area. 

Weight Management

SSM Health Weight Management Services offers a comprehensive weight-loss surgery program with the ultimate goal of helping people live better quality, healthier and longer lives. 

Wound Care

SSM Health Wound Centers follow national guidelines, based on clinical evidence when treating and managing wounds. Our centers offer state-of-the-art wound treatment improving our patient’s quality of life.

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